The Role of Ticks in the Epidemiology of Selected Transmissible Infectious Diseases
Niebieska okładka tomu 32 numer 2 z 2025 z żółtymi literami
PDF (Polish)

Keywords

tick-borne diseases
Lyme disease
tick-borne encephalitis
epidemiology
clinical symptoms
diagnostics
prevention
treatment

How to Cite

The Role of Ticks in the Epidemiology of Selected Transmissible Infectious Diseases. (2025). Review of Medical Practice, 31(2), 52-62. https://doi.org/10.26399/rmp.v31.2.2025/g.korzanska/r.niciak/a.lewczuk/m.szczygiel/r.gryczewski/

Abstract

Tick-borne diseases constitute a highly significant and continuously increasing health problem in Poland and Europe. The aim of the study is to discuss the most common infections caused by Borrelia burgdorferi s.l. and tick-borne encephalitis viruses, which are the most frequently reported tick-borne diseases in humans in European countries. The analysis included information on the nature of the etiological agent, clinical symptoms, diagnostic methods, treatment, and epidemiology of the mentioned diseases, collected based on current medical publications available in scientific databases. The study illustrates the scale of the problem and also draws attention to proper prophylaxis and appropriately selected diagnostics for patients with symptoms of infectious diseases.

PDF (Polish)

References

Nowak­Chmura M., Siuda K.: Ticks of Poland. Review of contemporary issues and latest research. Ann Parasitol 2012; 58(3): 125–155.

Kmieciak W., Ciszewski M., Szewczyk E.M.: Choroby odkleszczowe w Polsce – występowanie i trudności diagnostyczne. Medycyna Pracy 2016; 67(1): 73–87.

Barbour A.G., Benach J.L.: Discovery of the Lyme disease agent. mBio 2019; 10(5). doi: 10.1128/mBio.02166­19.

Kean W.F.: The musculoskeletal abnormalities of the Simi- laun Iceman (“ÖTZI”): Clues to chronic pain and possible treatments. Inflammopharmacology 2013; 21(1): 11–20. doi: 10.1007/s10787­012­0153­5.

Estrada­Peña A., Cutler S., Potkonjak A. i in.: An updated meta­analysis of the distribution and prevalence of Borrelia burgdorferi s.l. in ticks in Europe. Int J Health Geogr 2018; 17: 41. doi: 10.1186/s12942­018­0163­7.

Margos G., Vollmer S.A., Ogden N.H. i in.: Population genetics, taxonomy, phylogeny and evolution of Borrelia burg- dorferi sensu lato. Infect Genet Evol 2011; 11(7): 1545–1563. doi: 10.1016/j.meegid.2011.07.022.

Rudenko N., Golovchenko M., Ruzek D. i in.: Molecular detection of Borrelia bissettii DNA in serum samples from patients in the Czech Republic with suspected borreliosis. FEMS Microbiol Lett 2009; 292(2): 274–281. doi: 10.1111/j. 1574­6968.2009.01498.x.

Stanek G., Reiter M.: The expanding Lyme Borrelia complex – clinical significance of genomic species? Clin Microbiol Infect 2011; 17(4):487–493. doi: 10.1111/j. 1469­0691.2011.03492.x.

Da Franca I., Santos L., Mesquita T. i in.: Lyme borreliosis in Portugal caused by Borrelia lusitaniae? Clinical report on the first patient with a positive skin isolate. Wien Klin Wochenschr 2005; 117(11–12): 429–432. doi: 10.1007/s00508­005­ 0386­z.

Fingerle V., Schulte­Spechtel U.C., Ruzic­Sabljic E. i in.: Epidemiological aspects and molecular characterization of Borrelia burgdorferi s.l. from southern Germany with special respect to the new species Borrelia spielmanii sp. Nov. Int J Med Microbiol 2008; 298(3–4): 279–290. doi: 10.1016/j. ijmm.2007.05.002.

Pakanen V.M., Sormunen J.J., Sippola E. i in.: Questing abundance of adult taiga ticks Ixodes persulcatus and their Borrelia prevalence at the north­western part of their distribution. Parasit Vectors 2020; 13: 384. doi: 10.1186/s13071­ 020­04259­z.

Wilson K.D., Elston D.M.: What’s eating you? Ixodes tick and related diseases, part 1: life cycle, local reactions, and lyme disease. Cutis 2018; 101(3): 187–190.

Patrican L.A.: Absence of Lyme disease spirochetes in larval progeny of naturally infected Ixodes scapularis (Acari:Ixodi- dae) fed on dogs. J Med Entomol 1997; 34(1): 52–55. doi: 10.1093/jmedent/34.1.52.

Craine N.G., Nuttall P.A., Marriott A.C. i in.: Role of grey squirrels and pheasants in the transmission of Borrelia burgdorferi sensu lato, the Lyme disease spirochaete, in the U.K. Folia Parasitologica (Praha) 1997; 44(2): 155–160.

Hofmeester T., Coipan E.C., van Wieren S.E. i in.: Few vertebrate species dominate the Borrelia burgdorferi s.l. Life cycle. Environ Res Lett 2016; 11(4): 043001. doi: 10.1088/1748­ 9326/11/4/043001.

Majerová K., Honig V., Houda M. i in.: Hedgehogs, squirrels, and blackbirds as sentinel hosts for active surveillance of Borrelia miyamotoi and Borrelia burgdorferi complex in urban and rural environments. Microorganisms 2020; 8(12): 1908. doi: 10.3390/microorganisms 8121908.

Obiegała, A., Król N., Oltersdorf C. i in.: The enzootic life­cycle of Borrelia burgdorferi (sensu lato) and tick­borne rickettsiae: an epidemiological study on wild­living small mammals and their ticks from Saxony, Germany. Parasit Vectors 2017; 10: 115. doi: 10.1186/s13071­017­2053­4.

Mysterud A., Heylen D.J.A., Matthysen E. i in.: Lyme neuroborreliosis and bird populations in northern Europe. Proc Biol Sci 2019; 286(1903): 20190759. doi: 10.1098/ rspb.2019.0759.

Díaz P., Remesar S., Venzal J.M. i in.: Occurrence of Borrelia and Borreliella species in Ixodes ricinus collected from roe deer in northwestern Spain. Med Vet Entomol 2019; 33(3): 427–430. doi: 10.1111/mve.12364.

Hofmeester T.R., Krawczyk A., Docters van Leeuwen A. i in.: Role of mustelids in the life­cycle of ixodid ticks and transmission cycles of four tick­borne pathogens. Parasit Vectors 2018; 11(600): 1–13. doi: 10.1186/s13071­018­3126­8.

Mendoza­Roldan J A., Colella V., Lia R.P. i in.: Borrelia burgdorferi (sensu lato) in ectoparasites and reptiles in southern Italy. Parasites & Vectors 2019; 12(1): 35. doi: 10.1186/ s13071-019-3286-1.

Tilly K., Rosa P.A., Stewart P.E.: Biology of infection with Borrelia burgdorferi. Infect Dis Clin North Am 2008; 22(2): 217–234. doi: 10.1016/j.idc.2007.12.013.

Eisen L.: Pathogen transmission in relation to duration of attachment by Ixodes scapularis ticks. Ticks Tick Borne Dis 2018; 9(3): 535–542. doi: 10.1016/j.ttbdis.2018.01.002.

Cull B., Pietzsch M.E., Gillingham E.L. i in.: Seasonality and anatomical location of human tick bites in the United Kingdom. Zoonoses Public Health 2020; 67(2): 112–121. doi: 10.1111/zph.12659.

Littman M.P., Gerber B., Goldstein R.E. i in.: ACVIM consensus update on Lyme borreliosis in dogs and cats. J Vet Intern Med 2018; 32(3): 887–903. doi: 10.1111/jvim.15085.

Mead P.: Epidemiology of Lyme disease. Infect Dis Clin North Am, 2022; 36(3):495­521. doi: 10.1016/j.idc.2022.03.004.

Vu Hai V., Almeras L., Socolovschi C. i in.: Monitoring human tick­borne disease risk and tick bite exposure in Europe: available tools and promising future methods. Ticks Tick Borne Dis 2014; 5(6):607–619. doi: 10.1016/j.ttbdis.2014.07.022.

Semenza J.C.; Suk J.E.: Vector­borne diseases and climate change: A European perspective. FEMS Microbiol Lett 2018; 365(2): fnx244. doi: 10.1093/femsle/fnx244.

Jaenson T.G., Jaenson D.G.E., Eisen L. i in.: Changes in the geographical distribution and abundance of the tick Ixodes ricinus during the past 30 years in Sweden. Parasit Vectors 2012; 5: 8. doi: 10.1186/1756­3305­5­8.

Czarkowski M.P., Wielgosz U.: Choroby zakaźne i zatrucia w Polsce w 2023 roku. Warszawa: Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny – Państwowy Instytut Badawczy, Zakład Epidemiologii Chorób Zakaźnych i Nadzoru, Główny Inspektorat Sanitarny, Departament Przeciwepidemiczny i Ochrony Sanitarnej Granic; 2024. 1–176.

Vandekerckhove O., Buck E.D., Wijngaerden E.V.: Lyme disease in Western Europe: an emerging problem? A systematic review. Acta Clin Belg 2021; 76(3): 244–252. doi: 10.1080/17843286.2019.1694293.

Enkelmann J., Bohmer M., Patrierle V. i in.: Incidence of noti- fied Lyme borreliosis in Germany, 2013­2017. Sci Rep 2018; 8(1): 14976. doi: 10.1038/s41598­018­33136­0.

Septfons A., Goronflot T., Jaulhac B.: Epidemiology of Lyme borreliosis through two surveillance systems: the national Sentinelles GP network and the national hospital discharge database, France, 2005 to 2016. Euro Surveill 2019; 24(11): 1800134. doi: 10.2807/1560­7917.ES.2019.24.11.1800134.

Cairns V., Wallenhorst C., Rietbrock S. i in.: Incidence of Lyme disease in the UK: a population­based cohort study. BMJ 2019; 9(7): e025916. doi: 10.1136/bmjopen­2018­025916.

Vigfusson H.B., Hardarson H.S., Ludviksson B.R.: Lyme disease in Iceland – epidemiology from 2011 to 2015 [Icelandic]. Laeknabladid 2019; 105(2): 63–70. doi: 10.17992/ lbl.2019.02.215.

Stanek G., Strle F.: Lyme Disease – European perspective. Infect Dis Clin North Am 2008; 22(2): 327–339. doi: 10.1016/j.idc.2008.01.001.

Stanek G., Wormser G.P., Gray J. i in.: Lyme borreliosis. Lancet 2012; 379: 461–473. doi: 10.1016/S0140­6736 (11)60103­7.

National Guideline Centre (UK): Lyme disease: diagnosis and management. National Institute for Health and Care Excellence (NICE). Londyn: Clinical Guidelines nr 95; 2018. http://www.ncbi.nlm.nih.gov/books/NBK542111/ (dostęp: 26.02.2025).

Murray T.S., Shapiro E.D.: Lyme Disease. Clin Lab Med, 2010; 30(1): 311–328. doi: 10.1016 /j.cll.2010.01.003.

Cardenas­de la Garza J.A., De la Cruz­Valadez E., Ocam- po­Candiani J. i in.: Clinical spectrum of Lyme disease. Eur J Clin Microbiol Infect Dis 2019; 38(2): 201–208. doi: 10.1007/s10096­018­3417­1.

Arvikar S.L., Steere A.C.: Diagnosis and treatment of Lyme arthritis, Infect Dis Clin North Am 2015; 29(2): 269–280. doi: 10.1016/j.idc. 2015.02.004.

Maraspin V., Klevisar M.N., Ruzic­Sabljic E. i in.: Borrelial lymphocytoma in adult patients. Clin Infect Dis 2016; 63(7): 914–921. doi: 10.1093/cid/ciw417.

Garcia­Monco J.C., Benach J.L.: Lyme neuroborreliosis: clinical outcomes, controversy, pathogenesis, and polymicrobial infections. Ann Neurol 2019; 85(1): 21–31. doi: 10.1002/ ana.25389.

Cooper L., Branagan­Harris M., Tuson R. i in.: Lyme disease and Bell’s palsy: An epidemiological study of diagnosis and risk in England. Br J Gen Pract 2017; 67(658): e329–e335. doi: 10.3399/bjgp17X690497.

Ryberg B.: Bannwarth’s syndrome (lymphocytic meningoradiculitis) in Sweden. Yale J Biol Med 1984; 57(4): 499–503.

Träisk F., Lindquist L.: Optic nerve involvement in Lyme disease. Curr Opin Ophthalmol 2012; 23(6): 485–490. doi: 10.1097/ICU.0b013e328358b1eb.

Gade A., Matin T., Rubenstein R. i in.: Acrodermatitis Chronica Atrophicans, 2021; StatPearls. http://www.ncbi.nlm.nih.gov/books/NBK563289/ (dostęp: 17.02.2025).

Weiss T., Zhu P., White H. i in.: Latent Lyme disease resulting in chronic arthritis and early career termination in a United States army officer. Mil Med 2019; 184(7–8): e368–e370. doi: 10.1093/milmed/usz026.

Miklossy J.: Chronic or late Lyme neuroborreliosis: analysis of evidence compared to chronic or late neurosyphilis. Open Neurol J 2012; 6: 146–157. doi: 10.2174/ 1874205X 01206010146.

Rebman A.W., Aucott J.N.: Post­treatment Lyme disease as a model for persistent symptoms in Lyme disease. Front Med 2020; 7: 57. doi: 10.3389/fmed.2020.00057.

Smoleńska Z., Matyjasek A., Zdrojewski Z.: Borelioza – najnowsze rekomendacje w diagnostyce i leczeniu. Forum Reumatol 2016; 2(2): 58–64.

Semen P., Petersen J., Hinckley A.: Updated CDC recommendation for serologic diagnosis of Lyme disease. MMWR, 2019; 68(32): 703. doi: 10.15585/ mmwr.mm6832a4.

Talagrand­Reboul E., Raffetin A., Zachary P. i in.: Immunoserological diagnosis of human borrelioses: current knowledge and perspectives. Front Cell Infect Microbiol 2020; 10: 241. doi: 10.3389/fcimb.2020.00241.

De Martino S.J., Sordet Ch., Piemont Y. i in.: Enhanced culture of Borrelia garinii and Borrelia afzelii strains on a solid BSK­based medium in anaerobic conditions. Res Microbiol 2006; 157(8): 726–729. doi: 10.1016/j.resmic.2006.05.002.

Veinović G., Ruzic­Sabljic E., Strle F. i in.: Comparison of growth of Borrelia afzelii, Borrelia garinii, and Borrelia burgdorferi sensu stricto at five different temperatures. PloS One 2016; 11(6): e0157706. doi: 10.1371/journal.pone.0157706.

Pancewicz S.A., Garlicki A.M., Moniuszko­Malinowska A. i in.: Diagnostyka i leczenie chorób przenoszonych przez kleszcze. Rekomendacje Polskiego Towarzystwa Epidemiologów i Lekarzy Chorób Zakaźnych. Przegl Epidemiol 2015; 69: 421428.

Poland G.A., Jacobson R.M.: The prevention of Lyme disease with vaccine. Vaccine 2001; 19(17–19): 2303–2308. doi: 10.1016/s0264­410x(00)00520­x.

Kallio­Kokko H., Uzcategui N., Vapalahti O. i in.: Viral zoonoses in Europe. FEMS Microbiol Rev 2005; 29(5): 1051–1077. doi: 10.1016/j.femsre.2005.04.012.

Wengler G., Wengler G., Gross H.J.: Studies on virus­specific nucleic acids synthesized in vertebrate and mosquito cells infected with flaviviruses. Virology 1978; 89(2): 423–437. doi: 10.1016/0042­6822(78)90185­x.

Ecker M., Allison S.L., Meixner T. i in.: Sequence analysis and genetic classification of tick­borne encephalitis viruses from Europe and Asia. J Gen Virol 1999; 80: 179–185. doi: 10.1099/0022­1317­80­1­179.

Heinz F.X.: Molecular aspects of TBE virus research. Vaccine 2003; 21(1): 3–10. doi: 10.1016/s0264­410x (02)00820­4.

Siński E., Welc­Falęciak R.: Ryzyko zakażeń przenoszonych przez kleszcze w ekosystemach leśnych Polski. Zarządzanie Ochroną Przyrody w Lasach 2012; 6: 96–111.

Lindquist L., Vapalahti O.: Tick­borne encephalitis. Lancet 2008; 371(9627): 1861–1871. doi: 10.1016/S0140­ 6736(08)60800­4.

Offerdahl D.K., Clancy, N.G., Bloom M.E.: Stability of a tick­borne Flavivirus in milk. Front. Bioeng Biotechnol 2016; 4(40): 1–6. doi: 10.3389/fbioe.2016.00040.

Avšič­Zupanc T., Poljak M., Maticic M.: Laboratory acquired tick­borne meningoencephalitis: characterization of virus strains. Clin Diagn Virol 1995; 4: 51–59. doi: 10.1016/0928­ 0197 (94)00062­y.

Fiecek B., Matławska M., Gołąb E. i in.: Risk of transmission of tick­borne diseases by blood transfusion. Postępy Mikrobiol 2020; 59 (2): 129–137. doi: 10.21307/PM­2020.59.2.010.

Siuda K.: Kleszcze Polski (Acari: Ixodida). Cz. 2. Systematyka i rozmieszczenie. Monografie Parazytologiczne. Warszawa: Polskie Towarzystwo Parazytologiczne; 1993. 1–375.

Drelich A., Kruszyński P., Wąsik T.J.: Etiopatogeneza kleszczowego zapalenia mózgu (KZM). Ann Acad Med Siles 2012; 66(6): 4–56.

Chitimia­Dobler L., Lemhöfer G., Król N. i in.: Repeated isolation of tick­borne encephalitis virus from adult Dermacentor reticulatus ticks in an endemic area in Germany. Parasites Vectors 2019; 12: 90. doi: 10.1186/s13071­019­3346­6.

Hasle G. Transport of ixodid ticks and tick­borne pathogens by migratory birds. Front Cell Infect Microbiol 2013; 3: 48. doi:10.3389/fcimb.2013.00048.

Bušová, A., Dorko E., Feketeová E. i in.: Serostatus and risk factors of tick­borne encephalitis. Cent Eur J Public Health, 2018; 26 (Suppl.): S56–S60. doi: 10.2110/cejph.a5289.

Kilpatrick AM., Randolph S.E.: Drivers, dynamics, and control of emerging vector­borne zoonotic diseases. Lancet 2012; 380 (9857): 1946–1955. doi: 10.1016/S0140­ 6736(12)61151­9.

Stefanoff P., Rubikowska B., Bratkowski J. i in.: A predictive model has identified tick­borne encephalitis high­risk areas in regions where no cases were reported previously, Poland, 1999–2012. Int J Environ Res Public Health 2018; 15(4): 677. doi: 10.3390/ijerph15040677.

Stefanoff P., Zielicka­Hardy A., Hlebowicz M. i in.: New ende- mic foci of tick­borne encephalitis (TBE) identified in districts where testing for TBE was not available before 2009 in Po- land. Parasit Vectors 2013; 6: 180. doi: 10.1186/1756­3305­ 6-180.

Zajkowska, J., Moniuszko A., Czupryna P. i in.: Chorea and tick­borne encephalitis, Poland. Emerg Infect Dis 2013; 19(9): 1544–1545. doi: 10.3201/eid1909.130804.

European Centre for Disease Prevention and Control. Tic-k­borne encephalitis. In: ECDC. Annual epidemiological report for 2016. Stockholm: ECDC; 2018. https://www.ecdc. europa.eu/en/publications­data/tick­borne­encephalitis­an-nual­epidemiological­report­2016. Review of Medical Practice, 2025; Vol. XXXI, No. 262

European Centre for Disease Prevention and Control. Tick-borne encephalitis. In: ECDC. Annual epidemiological report for 2018. Stockholm: ECDC; 2019. https://www.ecdc.europa.eu/en/publications­data/tick­borne­encephalitis­an-nual­epidemiological­report­2018.

European Centre for Disease Prevention and Control. Tick-­borne encephalitis. In: ECDC. Annual epidemiological report for 2019. Stockholm: ECDC; 2021. https://www.ecdc.europa.eu/en/publications­data/tick­borne­encephalitis­an-nual­epidemiological­report­2019.

Czarkowski M.P., Cielebąk E., Staszewska­Jakubik E. i in.: Choroby zakaźne i zatrucia w Polsce w 2014 roku. Warszawa: Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, Zakład Epidemiologii, Główny Inspektorat Sani- tarny, Departament Zapobiegania oraz Zwalczania Zakażeń i Chorób Zakaźnych u Ludzi; 2015. 1–165.

Czarkowski M.P., Cielebąk E., Staszewska­Jakubik E. i in.: Choroby zakaźne i zatrucia w Polsce w 2015 roku. Warszawa: Narodowy Instytut Zdrowia Publicznego Państwowy Za- kład Higieny, Zakład Epidemiologii, Główny Inspektorat Sanitarny, Departament Zapobiegania oraz Zwalczania Zakażeń i Chorób Zakaźnych u Ludzi; 2016. 1–166.

Czarkowski M.P., Cielebąk E., Staszewska­Jakubik E. i in.: Choroby zakaźne i zatrucia w Polsce w 2016 roku. Warszawa: Narodowy Instytut Zdrowia Publicznego Państwowy Za- kład Higieny, Zakład Epidemiologii, Główny Inspektorat Sanitarny, Departament Zapobiegania oraz Zwalczania Zakażeń i Chorób Zakaźnych u Ludzi; 2017. 1–166.

Czarkowski M.P., Cielebąk E., Staszewska­Jakubik E. i in.: Choroby zakaźne i zatrucia w Polsce w 2017 roku. Warszawa: Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, Zakład Epidemiologii Chorób Zakaźnych i Nadzoru, Główny Inspektorat Sanitarny, Departament Przeciwepidemiczny i Ochrony Sanitarnej Granic; 2018. 1–168.

Czarkowski M.P., Cielebąk E., Kondej B. i in.: Choroby zakaźne i zatrucia w Polsce w 2018 roku. Warszawa: Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, Zakład Epidemiologii Chorób Zakaźnych i Nadzoru, Główny Inspektorat Sanitarny, Departament Przeciwepidemiczny i Ochrony Sanitarnej Granic; 2019. 1–168.

Czarkowski M.P., Niewęgłowska A., Szmulik­Misiurek K. i in.: Choroby zakaźne i zatrucia w Polsce w 2019 roku. War- szawa: Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, Zakład Epidemiologii Chorób Zakaźnych i Nadzoru, Główny Inspektorat Sanitarny, Departament Przeciwepidemiczny i Ochrony Sanitarnej Granic; 2020. 1–168.

Bojkiewicz E., Toczykowski K., Sulik A.: Tick­borne encephalitis – a review of current epidemiology, clinical symptoms, management, and prevention. Przegl Epidemiol 2020; 74(2): 316–325. doi: 10.32394/pe.74.24.

Blaškovič D., Pučekova G., Kubínyi L. i in.: An epidemiological study of tick­borne encephalitis in the Tribeč region: 1953­63. Bull World Health Organ 1967; 36(Suppl. 1): 89–95. PMID: 5298547.

Honig V., Carolan H.E., Vavruskova Z. i in.: Broad­range survey of vector­borne pathogens and tick host identification of Ixodes ricinus from Southern Czech Republic. FEMS Microbiol Ecol 2017; 93: fix129.

Laursen K., Knudsen J.D.: Tick­borne encephalitis: A retrospective study of clinical cases in Bornholm, Denmark. Scand J Infect Dis 2003; 35(5): 354–357. doi: 10.1080/003655 40310005305.

Süss, J.: Tick­borne encephalitis in Europe and beyond – the epidemiological situation as of 2007. Euro Surveill 2008; 13(26): 18916. doi: 10.2807/ese.13.26.18916­en.

Dobler G., Zöller G., Poponnikova T. i in.: Tick­borne encephalitis virus in a highly endemic area in Kemerovo (western Siberia, Russia). Int J Med Microbiol 2008; 298: 94–101.

Krotkova E.N., Babaeva I.V., Bogutskiy M. i in.: Epidemiological and clinical features of tick­borne encephalitis in north­western region of Belarus. Przegl Epidemiol 2016; 70(3): 436–443.

Špitalská E., Boldisova E., Stefanidesova K. i in.: Pathogenic microorganisms in ticks removed from Slovakian residents over the years 2008–2018. Ticks Tick Borne Dis 2021; 12(2): 101626. doi: 10.1016/j.ttbdis.2020.101626.

Human Animal Infections Risk Surveillance Group. HAIRS risk assessment: tick­borne encephalitis. Qualitative assess- ment of the risk that tick­borne encephalitis presents to the UK population. London: Public Health England; 2019. https://www.gov.uk/government/publications/ hairs­risk­assessment­tick­borne­encephalitis.

Egyed L., Élő P., Sréter­Lancz Z. i in.: Seasonal activity and tick­borne pathogen infection rates of Ixodes ricinus ticks in Hungary. Ticks Tick Borne Dis 2012; 3(2): 90–94. doi: 10.1016/j.ttbdis.2012.01.002.

Kaiser R.: The clinical and epidemiological profile of tick­borne encephalitis in Southern Germany 1994–98: A Prospective Study of 656 Patients. Brain 1999; 122(11): 2067–2078. doi: 10.1093/brain/122.11.2067.

Mickienė A., Laiškonis A., Günther G. i in.: Tick­borne encephalitis in an area of high endemicity in Lithuania: disease severity and long­term prognosis. Clin Infect Dis 2002; 35(6): 650–658. doi: 10.1086/342059.

Bogovic P., Lotric­Furlan S., Strle F.: What tick­borne encephalitis may look like: clinical signs and symptoms. Travel Med Infect Dis 2010; 8: 246–250. doi: 10.1016/j.tmaid.2010.05.011.

Kaiser R.: Tick­borne encephalitis. Infect Dis Clin North Am 2008; 22(3): 561–575. doi: 10.1016/j.idc.2008.03.013.

Mansfield K.L., Johnson N., Phipps L.P. i in.: Tick­borne encephalitis virus – a review of an emerging zoonosis. J Gen Virol 2009; 90(Pt 8): 1781–1794. doi: 10.1099/vir.0.011437­0.

Herzig R., Patt C.M., Prokes T.: An uncommon severe clinical course of European tick­borne encephalitis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2002; 146(2): 63–67. doi: 10.5507/bp.2002.013.

Diaz J.H.: Ticks, including tick paralysis. In: Mandell G.L., Bennrtt J.E. Dolin R. (eds.): Principles and Practice of Infec- tious Diseases. Elsevier 2014: 3266–3279.

Pfeffer M., Dobler G.: Tick­borne encephalitis virus in dogs – is this an issue? Parasit Vectors 2011; 4: 59. doi: 10.1186/1756­3305­4­59.

Litzba N., Zelená H., Kreil T.R. i in.: Evaluation of different serological diagnostic methods for tick­borne encephalitis virus: enzyme­linked immunosorbent, immunofluorescence, and neutralization assay. Vector Borne Zoonotic Dis 2014; 14(2): 149–159. doi: 10.1089/vbz.2012.1287.

Albinsson B., Jääskeläinen A.E., Värv K. i in.: Multi­laboratory evaluation of ReaScan TBE IgM Rapid Test 2016 to 2017. Euro Surveill 2020; 25(12). doi: 10. 2807/1560­7917.ES. 2020. 25.12.1900427.

Günther G., Haglund M., Lindquist L. i in.: Intrathecal IgM, IgA and IgG antibody response in tick­borne encephalitis. Long­term follow­up related to clinical course and outcome. Clin Diagn Virol 1997; 8(1): 17–29. doi: 10.1016/S0928­0197 (97)00273­0.

Reusken C., Boonstra M., Rugebregt S. i in.: An evaluation of serological methods to diagnose tick­borne encephalitis from serum and cerebrospinal fluid. J Clin Virol 2019; 120: 78–83. doi: 10.1016/j.jcv.2019.09.009.

Bogovic P., Strle F.: Tick­borne encephalitis: A review of epidemiology, clinical characteristics, and management. World J Clin Cases 2015; 3(5): 430–441. doi: 10.12998/wjcc. v3.i5.430.

Dörrbecker B., Dobler G., Spiegel M. i in.: Tick­borne encephalitis virus and the immune response of the mammalian host. Travel Med Infect Dis 2010; 8: 213–222. doi: 10.1016 /j.tmaid.2010.05.010.

Brouqui P., Bacellar F., Baranton G. i in.: Guidelines for the diagnosis of tick­borne bacterial diseases in Europe. Clin Microbiol Infect 2004; 10(12): 1108–1132. doi: 10.1111/j. 1469­0691.2004.01019.x.

Hayasaka D., Aoki K., Morita K.: Development of simple and rapid assay to detect viral RNA of tick­borne encephalitis vi- rus by reverse transcription­loop­mediated isothermal amplification. Virol J 2013; 10: 68. doi: 10.1186/1743­422X­10­68.

Holzmann H.: Diagnosis of tick­borne encephalitis. Vaccine 2003; 21: S36–S40. doi: 10.1016/S0264­410X (02)00819­8.

Dumpis U., Crook D., Oksi J.: Tick­borne encephalitis. Clin Infect Dis 1999; 28(4): 882–890. doi: 10.1086/515195.

Petri E., Gniel D., Zent O. Tick­borne encephalitis (TBE) trends in epidemiology and current and future management. Travel Med Infect Dis 2010; 8(4): 233–245. doi: 10.1016/j.tmaid.2010.08.001.

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